期刊
RHEUMATOLOGY
卷 50, 期 5, 页码 862-870出版社
OXFORD UNIV PRESS
DOI: 10.1093/rheumatology/keq404
关键词
B lymphocyte stimulator; A proliferation-inducing antigen; TACI-Ig; Arthritis; Autoimmune; T cell
类别
资金
- National Natural Science Foundation of China [30973543]
- Young Talents Foundation of the Education Department of Anhui Province [2010SQRL067]
- Natural Science Foundation of the Education Department of Anhui Province [KJ2010B406, KJ2010B398]
Methods. Rats with experimental arthritis were randomly separated into different groups and then treated with TACI-Ig (0.7, 2.1, 6.3 mg/kg), rhTNFR-Fc (2.8 mg/kg), MTX (0.5 mg/kg) or IgG-Fc (6.3 mg/kg), from Day 16 to Day 34 after immunization. Arthritis was evaluated by hind paw swelling, polyarthritis index and histopathological examination. Activities of BLyS, APRIL, IL-1 beta, IL-2, IL-10, TGF-beta 1, PGE(2), TNF-alpha, IFN-gamma, immunoglobulin (Ig)G1, IgG2a, IgM and IgA were assessed by ELISA. Cluster of differentiation (CD)20 expression was detected by immunohistochemical analysis. Results. TACI-Ig (2.1, 6.3 mg/kg) treatment significantly reduced the severity of established arthritis using the methods of clinical observation and histopathological examination. TACI-Ig treatment inhibited expression of IgM, decreased the expression of BLyS and APRIL and regulated the balance of pro-inflammatory and anti-inflammatory cytokines in serum of AA rats. Immunohistochemical analysis demonstrated that CD20 production was reduced in spleen. Conclusions. Data presented here demonstrate that administration of TACI-Ig significantly attenuates progression of experimental arthritis, with reductions in inflammatory response and bone and joint destruction.
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