期刊
RHEUMATOLOGY
卷 48, 期 11, 页码 1424-1428出版社
OXFORD UNIV PRESS
DOI: 10.1093/rheumatology/kep243
关键词
Genealogy database; Heritability; Psoriatic arthritis; Familial; Genetic
类别
资金
- University Hospital in Iceland
- Society for Rheumatology in Iceland
- Wyeth Rheumatology Foundation in Iceland
Objective. We have studied the prevalence of PsA in Reykjavik, Iceland, in a population-based cohort, and using the Icelandic genealogy database we have estimated the risk ratio (FIR) spanning five generations. Methods. The national identification numbers of all 220 living Icelanders in Reykjavik known to have PsA were linked with the genealogy database. RRs for developing PsA were estimated in first-degree relatives (FDRs) to fifth-degree relatives of PsA cases. The kinship coefficient (KC) for PsA was also calculated. The control populations were 1000 and 10000 sets of matched Icelandic subjects for each proband, respectively. Results. FDRs to fourth-degree relatives of patients with PsA had FIRS of 39, 12, 3.6 and 2.3, respectively (all P-values < 0.0001), reflecting a strong genetic component, whereas the fifth-degree relatives had an FIR of 1.2 (P=0.236). KCs of 5.0, 3.4, 1.7, 1.3, 1.0, 0.8 and 0.7 were observed for the first seven excluded meioses (all P-values < 0.0001), confirming the familial risk. Conclusions. Patients with PsA in Reykjavik, Iceland, are significantly more related to each other than to randomly sampled control subjects. This is in agreement with previous reports, but the present study examines the inheritance in more distantly related individuals. These findings indicate that in addition to a strong and complex genetic component in PsA, there is an important environmental contribution.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据