期刊
RHEUMATOLOGY
卷 48, 期 6, 页码 638-642出版社
OXFORD UNIV PRESS
DOI: 10.1093/rheumatology/kep077
关键词
Behets disease; Toll-like receptor 4; Korea; Polymorphism
类别
资金
- Ministry of Health, Labor and Welfare
- Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan
Objectives. HLA-B51 is strongly associated with Behets disease (BD) in any ethnic background. We recently reported that another gene, Toll-like receptor-4 (TLR4) is also implicated in BD in a Japanese population. To confirm these results, we investigated polymorphisms in the TLR4 gene in Korean patients with BD. Methods. In this study, 119 patients with BD and 141 healthy controls were enrolled; every participant was a Korean. Nine single nucleotide polymorphisms previously detected in TLR4 by direct sequencing were analysed for an association with BD. Results. The most frequent haplotype, TAGCGGTAA, was significantly increased in HLA-B51-positive BD patients (49.5), compared with healthy control participants [32.3; P0.029; odds ratio (OR)2.01; 95 CI 1.253.23]. This haplotype was also significantly increased in BD patients with arthritis (48.2; P0.003; OR1.96; 95 CI 1.263.26). There were no significant differences in the allele and genotype frequencies of patients and controls for each single nucleotide polymorphism. Conclusions. The haplotype of TLR4 may increase the risk for developing BD and the complication of arthritis in the Korean population.
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