期刊
RHEUMATOLOGY
卷 48, 期 9, 页码 1021-1028出版社
OXFORD UNIV PRESS
DOI: 10.1093/rheumatology/kep112
关键词
Rheumatoid arthritis; Methotrexate; Biologics; Biomarkers predictive of response; Pharmacogenetics; Pharmacogenomics
类别
资金
- French Ministry for Research and Arthritis Foundation
- French Society of Rheumatology
This review briefly recapitulates the existing markers predictive of RA responsiveness to treatment, focusing on MTX alone or combined with a biologic. In addition to the demographic and clinical factors, an update is provided of the predictive biomarkers identified by large-scale gene and protein analyses that generated new insights into the ability of high-throughput analysis of biological systems to select new potential indicators. Among the large-scale analysis tools now available, pharmacogenetics and pharmacogenomics (including transcriptomic and proteomic approaches) have been shown to provide such new putative biomarkers of therapeutic responses.
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