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Clinical Perspectives on Lupus Genetics Advances and Opportunities

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出版社

W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.rdc.2014.04.002

关键词

SLE; Lupus; Genetics; Clinical subphenotypes; GWAS; Nephritis; Autoantibodies

资金

  1. NIAID NIH HHS [U19 AI082714, U01 AI101934] Funding Source: Medline
  2. NIAMS NIH HHS [P30 AR053483] Funding Source: Medline
  3. NIGMS NIH HHS [P30 GM103510, U54 GM104938] Funding Source: Medline

向作者/读者索取更多资源

In recent years, genome-wide association studies have led to an expansion in the identification of regions containing confirmed genetic risk variants within complex human diseases, such as systemic lupus erythematosus (SLE). Many of the strongest SLE genetic associations can be divided into groups based on their potential roles in different processes implicated in lupus pathogenesis, including ubiquitination, DNA degradation, innate immunity, cellular immunity, lymphocyte development, and antigen presentation. Recent advances have also shown several genetic associations with SLE subphenotypes and subcriteria. Many areas for further exploration remain to move lupus genetic studies toward clinically informative end points.

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