期刊
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
卷 35, 期 2, 页码 263-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.rdc.2009.05.006
关键词
Modulation; Fibromyalgia; Chronic pain; Diffuse noxious inhibitory control; Analgesia
类别
资金
- NIAMS NIH HHS [R01 AR053541-03, R01 AR053541] Funding Source: Medline
- NINDS NIH HHS [R01 NS038767-08, R01 NS038767] Funding Source: Medline
Many chronic pain syndromes are associated with hypersensitivity to painful stimuli and with reduced endogenous pain inhibition. These findings suggest that modulation of pain-related information may be linked to the onset or maintenance of chronic pain. The combination of heightened pain sensitivity and reduced pain inhibition seems to predispose individuals to greater risk for increased acute clinical pain. It is unknown whether such pain processing abnormalities may also place individuals at increased risk for chronic pain. Psychophysical methods can be used for the evaluation of pain sensitivity and pain inhibition. Long-term prospective studies that could yield insight into the role of heightened pain sensitivity and pain disinhibition for the development of chronic pain disorders like fibromyalgia in the general population are lacking, however.
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