期刊
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
卷 34, 期 4, 页码 847-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.rdc.2008.08.003
关键词
Sjogren's syndrome; Genetics; HLA; Association
类别
资金
- NIH [DE015223, AR42460, AR12253, AR48940, AR62277, RR020143, AI24717]
- Department of Veteran Affairs Merit Award (JBH) [AR050782, AR043274]
- Alliance for Lupus Research
The evidence for a strong genetic component conferring susceptibility to primary Sjogren's syndrome (SS) is mounting. Several associations with SS have been reported and provide evidence that the HLA region harbors important susceptibility loci and that multiple genes outside the HLA region play a role. Genetic discovery lags behind success observed in related autoimmune diseases. Identifying genetic factors that cause SS will allow more precise definition of pathogenic mechanisms leading to the overall SS phenotype and clinically heterogeneous subsets of patients. Critical opportunities are certain to follow for translation into improved diagnosis and therapies for SS and its spectrum diseases.
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