期刊
ONCOTARGET
卷 6, 期 11, 页码 9031-9044出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.3320
关键词
wild-type p53 induced phosphatase 1 (WIP1); adenoid cystic carcinoma (ACC); salivary gland; invasion; metastasis
资金
- National Natural Science Foundation of China [81361120399, 81272961, 81372891]
- Fundamental Research Funds of the Central Universities of China
- State Key Laboratory of Oral Diseases Special Funded Projects [SKLOD201512]
The wild-type p53 induced phosphatase 1 (WIP1) is an oncogene overexpressed in a variety of human cancers. Here, we demonstrated that WIP1 silencing reduced MMP-9 and VEGF-C expression as well as migration and invasion of salivary adenoid cystic carcinoma (ACC) cells. Overexpression of MMP-9 or VEGF-C restored migration and invasion in WIP1 knockdown cells, indicating that MMP-9 and VEGF-C are downstream targets of WIP1 signaling. Levels of cyclin D1 and c-Myc, targets of Wnt/beta-catenin pathway, were significantly decreased by WIP1 silencing. In addition, WIP1 expression was positively associated with metastasis and prognosis of ACC patients as well as with MMP-9 or VEGF-C in ACC tissues.
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