期刊
ONCOTARGET
卷 6, 期 41, 页码 43831-43842出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.6257
关键词
Bim; miR-24; pancreatic cancer; tumorigenesis; angiogenesis
资金
- National Natural Science Foundation of China [81201946, 81372394, 81572321]
- National research platform of clinical evaluation technology for new anticancer drugs [81572321, 2013ZX09303001]
- Ministry of Education Research Fund for doctoral program [2012202120013]
- Tianjin Science Foundation [15JCYBJC28200]
- Science foundation of Medical University Of Tianjin [2011KY15]
miRNAs are a group of small RNAs that have been reported to play a key role at each stage of tumorigenesis and are believed to have future practical value. We now demonstrate that Bim, which stimulates cell apoptosis, is obviously down-regulated in pancreatic cancer (PaC) tissues and cell lines. And Bim-related miR-24 is significantly up-regulated in PaC. The repressed expression of Bim is proved to be a result of miR-24, thus promoting cell growth of both cancer and vascular cells, and accelerating vascular ring formation. By using mouse tumor model, we clearly showed that miR-24 promotes tumor growth and angiogenesis by suppressing Bim expression in vivo. Therefore, a new pathway comprising miR-24 and Bim can be used in the exploration of drug-target therapy of PaC.
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