期刊
ONCOTARGET
卷 6, 期 17, 页码 15449-15463出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.3913
关键词
2-methoxyestradiol; neuronal nitric oxide synthase; reactive nitrogen species; nitric oxide; osteosarcoma
资金
- National Science Center resources [2012/07/B/NZ1/00010]
- GraphPad Prism 6 for statistical analysis
- LAS 500 (GE Healthcare) for Western blot analysis
2-Methoxyestradiol (2-ME) is a physiological metabolite of 17 beta- estradiol. At pharmacological concentrations, 2-ME inhibits colon, breast and lung cancer in tumor models. Here we investigated the effect of physiologically relevant concentrations of 2-ME in osteosarcoma cell model. We demonstrated that 2-ME increased nuclear localization of neuronal nitric oxide synthase, resulting in nitro-oxidative DNA damage. This in turn caused cell cycle arrest and apoptosis in osteosarcoma cells. We suggest that 2-ME is a naturally occurring hormone with potential anti-cancer properties.
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