期刊
ONCOTARGET
卷 6, 期 16, 页码 14026-14032出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.4334
关键词
miR-34a; colorectal cancer; IL-6R; STAT3; inflammation
资金
- DFG
- Deutsche Krebshilfe
- Else-Kroner-Fresenius-Stiftung
- Friedrich-Baur-Stfitung
- Rudolf-Barlting-Stiftung
We previously reported that IL-6R, STAT3 and miR-34a form a positive feedback-loop, which promotes epithelial to mesenchymal transition (EMT), invasion, and metastasis of colorectal cancer (CRC) [1]. In that study only the membrane-bound form of the IL-6R was shown to be repressed by miR-34a. Here, we show that also the mRNA encoding the soluble IL6R (s-IL-6R) is directly targeted and repressed by miR-34a. Accordingly, the concentration of s-IL6R protein was decreased in conditioned media of CRC cell lines ectopically expressing miR-34a. The s-IL-6R mediates IL-6 trans-signaling, which also affects cells that do not express the IL-6R. Since IL-6 trans-signaling is involved in numerous inflammatory disease states these findings may be relevant for future therapeutic approaches.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据