期刊
ONCOTARGET
卷 6, 期 39, 页码 41856-41862出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.6170
关键词
liver metastasis; colon cancer; RFP; nude mice; orthotopic models
资金
- National Cancer Institute [CA132971, CA142669]
- JSPS KAKENHI grant [26830081, 26462070, 24592009]
- Grants-in-Aid for Scientific Research [26830081, 26462070] Funding Source: KAKEN
Colon cancer liver metastasis is often the lethal aspect of this disease. Wellisolated metastases are candidates for surgical resection, but recurrence is common. Better adjuvant treatment is therefore needed to reduce or prevent recurrence. In the present study, HT-29 human colon cancer cells expressing red fluorescent protein (RFP) were used to establish liver metastases in nude mice. Mice with a single liver metastasis were randomized into bright-light surgery (BLS) or the combination of BLS and adjuvant treatment with tumor-targeting S. typhimurium A1-R. Residual tumor fluorescence after BLS was clearly visualized at high magnification by fluorescence imaging. Adjuvant treatment with S. typhimurium A1-R was highly effective to increase survival and disease-free survival after BLS of liver metastasis. The results suggest the future clinical potential of adjuvant S. typhimurium A1-R treatment after liver metastasis resection.
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