期刊
ONCOTARGET
卷 6, 期 16, 页码 14153-14164出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.3686
关键词
miR-221/222; pancreatic cancer; Matrix metalloproteinases
资金
- Fundamental Research Funds for the Central Universities in Xi'an Jiaotong University [2014-15, 2014-15-R2 08143063, 08143069]
- Science Technology Star Grant from Commission of Science Technology of Shaanxi province, China
MicroRNAs are involved in the initiation and progression of pancreatic cancer. In this study, we showed that miR-221/222 is overexpressed in pancreatic cancer. MiR-221/222 overexpression significantly promoted pancreatic cancer cell proliferation and invasion while inhibiting apoptosis. The expression of the matrix metalloproteinases ( MMPs) MMP-2 and MMP-9 was increased in miR-221/222 mimic-transfected pancreatic cancer cells. Validation experiments identified TIMP-2 as a direct target of miR-221/222. These data indicate that overexpressed miR-221/222 may play an oncogenic role in pancreatic cancer by inducing the expression of MMP-2 and MMP-9, thus leading to cancer cell invasion.
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