期刊
ONCOTARGET
卷 6, 期 10, 页码 7758-7773出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.3483
关键词
muscle atrophy; cachexia; fish oil; selenium; chemotherapy
资金
- Ministry of Science and Technology, Taiwan, ROC [NSC101-2313-B-019-010, NSC102-2628-B-019-001-MY3]
Chemotherapy can cause cachexia, which is manifested by weight loss, inflammation and muscle atrophy. However, the mechanisms of tumor and chemotherapy on skeletal muscle proteolysis, remained unclear. In this report, we demonstrated that tumor-induced myostatin in turn induced TNF-alpha, thus activating calcium-dependent and proteasomal protein degradation. Chemotherapy activated myostatin-mediated proteolysis and muscle atrophy by elevating IL-6. In tumor-bearing mice under chemotherapy, supplementation with fish oil and selenium prevented a rise in IL-6, TNF-alpha and myostatin and muscle atrophy. The findings presented here allow us to better understand the molecular basis of cancer cachexia and potentiate nutrition supplementation in future cancer chemotherapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据