期刊
NUTRIENTS
卷 7, 期 11, 页码 9453-9474出版社
MDPI
DOI: 10.3390/nu7115475
关键词
lipotoxicity; lipolysis; de novo lipogenesis; glyceroneogenesis; fatty liver; NAFLD; ectopic fat; HCC; SCD-1; saturated fat
资金
- FP7 [HEALTH-F22009- 241762]
- MIUR grant Progetto Bandiera INTEROMICS
- MIUR grant Progetto Premiale Environment, life style and cardiovascular diseases: from molecules to man
- fellowship Dottorato Pegaso Regione Toscana in Biochemistry and Molecular Biology
- GILEAD fellowship
Excessive accumulation of lipids can lead to lipotoxicity, cell dysfunction and alteration in metabolic pathways, both in adipose tissue and peripheral organs, like liver, heart, pancreas and muscle. This is now a recognized risk factor for the development of metabolic disorders, such as obesity, diabetes, fatty liver disease (NAFLD), cardiovascular diseases (CVD) and hepatocellular carcinoma (HCC). The causes for lipotoxicity are not only a high fat diet but also excessive lipolysis, adipogenesis and adipose tissue insulin resistance. The aims of this review are to investigate the subtle balances that underlie lipolytic, lipogenic and oxidative pathways, to evaluate critical points and the complexities of these processes and to better understand which are the metabolic derangements resulting from their imbalance, such as type 2 diabetes and non alcoholic fatty liver disease.
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