期刊
NUTRIENTS
卷 7, 期 7, 页码 5764-5782出版社
MDPI
DOI: 10.3390/nu7075246
关键词
antioxidants; Alzheimer's disease; fibrillogenesis; oxidative stress; apoptosis; nanotechnology
资金
- Italian National Operational Program for Research and Competitiveness (project name: Di.Me.Sa-Valorization of typical products of Mediterranean diet and their use for healthy and nutraceutical purposes) [PON02_00667-PON02_00451_3361785]
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the deposition of extracellular amyloid-beta peptide (A) and intracellular neurofibrillar tangles, associated with loss of neurons in the brain and consequent learning and memory deficits. A is the major component of the senile plaques and is believed to play a central role in the development and progress of AD both in oligomer and fibril forms. Inhibition of the formation of A fibrils as well as the destabilization of preformed A in the Central Nervous System (CNS) would be an attractive therapeutic target for the treatment of AD. Moreover, a large number of studies indicate that oxidative stress and mitochondrial dysfunction may play an important role in AD and their suppression or reduction via antioxidant use could be a promising preventive or therapeutic intervention for AD patients. Many antioxidant compounds have been demonstrated to protect the brain from A neurotoxicity. Ferulic acid (FA) is an antioxidant naturally present in plant cell walls with anti-inflammatory activities and it is able to act as a free radical scavenger. Here we present the role of FA as inhibitor or disaggregating agent of amyloid structures as well as its effects on biological models.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据