期刊
NPG ASIA MATERIALS
卷 7, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/am.2015.114
关键词
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资金
- NSF-INSPIRE Grant [DMR-1242240]
- Korean government, MSIP [2007-00107, 2013M3A9D3045719]
- NSF [CMMI-1300846, CMMI-1400169]
- NIH [R01EB019337]
- Weldon School of Biomedical Engineering and the School of Mechanical Engineering at Purdue University
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [1242240] Funding Source: National Science Foundation
- Directorate For Engineering
- Div Of Civil, Mechanical, & Manufact Inn [1400169] Funding Source: National Science Foundation
On-demand, localized release of drugs in precisely controlled, patient-specific time sequences represents an ideal scenario for pharmacological treatment of various forms of hormone imbalances, malignant cancers, osteoporosis, diabetic conditions and others. We present a wirelessly operated, implantable drug delivery system that offers such capabilities in a form that undergoes complete bioresorption after an engineered functional period, thereby obviating the need for surgical extraction. The device architecture combines thermally actuated lipid membranes embedded with multiple types of drugs, configured in spatial arrays and co-located with individually addressable, wireless elements for Joule heating. The result provides the ability for externally triggered, precision dosage of drugs with high levels of control and negligible unwanted leakage, all without the need for surgical removal. In vitro and in vivo investigations reveal all of the underlying operational and materials aspects, as well as the basic efficacy and biocompatibility of these systems.
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