期刊
NEUROSCIENCE BULLETIN
卷 31, 期 6, 页码 717-734出版社
SPRINGER
DOI: 10.1007/s12264-015-1567-z
关键词
ischemic stroke; hemorrhagic stroke; animal model; inflammatory cells
资金
- National Institute on Aging [R01 AG031811, R01 AG037506]
- National Institute of Neurological Disorders and Stroke [R01 NS083078-01A1, R41 NS080329-01A1]
- American Heart Association grant [14GRNT20460026]
- National Natural Science Foundation of China [81300993, 81571145]
Stroke, including cerebral ischemia, intracerebral hemorrhage, and subarachnoid hemorrhage, is the leading cause of long-term disability and death worldwide. Animal models have greatly contributed to our understanding of the risk factors and the pathophysiology of stroke, as well as the development of therapeutic strategies for its treatment. Further development and investigation of experimental models, however, are needed to elucidate the pathogenesis of stroke and to enhance and expand novel therapeutic targets. In this article, we provide an overview of the characteristics of commonly-used animal models of stroke and focus on the inflammatory responses to cerebral stroke, which may provide insights into a framework for developing effective therapies for stroke in humans.
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