期刊
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
卷 19, 期 1B, 页码 212-217出版社
SOC BRASILEIRA FARMACOGNOSIA
DOI: 10.1590/S0102-695X2009000200006
关键词
Eugenia caryophyllata; Syzygium aromaticum; Myrtaceae; anti-inflammatory activity; antinociceptive activity; essential oil; clove
资金
- Fundacao Araucaria, Parana, Brazil
Eugenia caryophyllata, popular name clove, is grown naturally in Indonesia and cultivated in many parts,of the world, including Brazil. Clove is used,in cooking, food processing, pharmacy, perfumery, cosmetics and the clove oil (eugenol) have been used in folk medicine for manifold conditions include use in dental care, as an antiseptic and analgesic. The objective-of this study was evaluated the anti-inflammatory and. antinociceptive activity of eugenol used for dentistry purposes following oral administration in animal models in vivo. The anti-inflammatory activity of eugenol was evaluated by inflammatory exudates volume and leukocytes migration in carrageenan-induced pleurisy and carrageenan-induced paw edema tests in rats. The antinociceptive activity was evaluated using the acetic acid-induced writhing and hot-plate tests in mice. Eugenol (200 and 400 mg/kg) reduced the volume of pleural exudates without changing the total blood leukocyte counts. At dose of 200 mg/kg, eugenol significantly inhibited carrageenan-induced edema, 2-4 h after injection of the flogistic agent. In the hot-plate test, eugenol administration (100 mg/kg) showed unremarkable activity against the time-to-discomfort reaction recorded as response latency, which is blocked by meperidine. Eugenol at doses of 50, 75 and 100 mg/kg had a significant antinociceptive effect in the test of acetic-acid-induced abdominal writhing, compared to the control animals. The data suggest that eugenol possesses anti-inflammatory and peripheral antinociceptive activities.
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