相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Mechanisms Underlying Inflammation in Neurodegeneration
Christopher K. Glass et al.
CELL (2010)
Regulatory T Cells Attenuate Th17 Cell-Mediated Nigrostriatal Dopaminergic Neurodegeneration in a Model of Parkinson's Disease
Ashley D. Reynolds et al.
JOURNAL OF IMMUNOLOGY (2010)
Protective autoimmunity functions by intracranial immunosurveillance to support the mind: The missing link between health and disease
M. Schwartz et al.
MOLECULAR PSYCHIATRY (2010)
Can Alzheimer disease be prevented by amyloid-β immunotherapy?
Cynthia A. Lemere et al.
NATURE REVIEWS NEUROLOGY (2010)
Long-Term Follow-Up of Patients Immunized with AN1792: Reduced Functional Decline in Antibody Responders
Bruno Vellas et al.
CURRENT ALZHEIMER RESEARCH (2009)
Prefilament tau species as potential targets for immunotherapy for Alzheimer disease and related disorders
Rakez Kayed et al.
CURRENT OPINION IN IMMUNOLOGY (2009)
Detecting Morphologically Distinct Oligomeric Forms of α-Synuclein
Sharareh Emadi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome
Leslie Michels Thompson et al.
JOURNAL OF CELL BIOLOGY (2009)
Intrabody Gene Therapy Ameliorates Motor, Cognitive, and Neuropathological Symptoms in Multiple Mouse Models of Huntington's Disease
Amber L. Southwell et al.
JOURNAL OF NEUROSCIENCE (2009)
Generating Differentially Targeted Amyloid-β Specific Intrabodies as a Passive Vaccination Strategy for Alzheimer's Disease
Kelly L. Sudol et al.
MOLECULAR THERAPY (2009)
Polyglutamine disruption of the huntingtin exon 1 N terminus triggers a complex aggregation mechanism
Ashwani K. Thakur et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2009)
18-Month study of intravenous immunoglobulin for treatment of mild Alzheimer disease
Norman R. Relkin et al.
NEUROBIOLOGY OF AGING (2009)
IV immunoglobulin is associated with a reduced risk of Alzheimer disease and related disorders
H. Fillit et al.
NEUROLOGY (2009)
A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease
S. Salloway et al.
NEUROLOGY (2009)
Serines 13 and 16 Are Critical Determinants of Full-Length Human Mutant Huntingtin Induced Disease Pathogenesis in HD Mice
Xiaofeng Gu et al.
NEURON (2009)
The Transcellular Spread of Cytosolic Amyloids, Prions, and Prionoids
Adriano Aguzzi et al.
NEURON (2009)
Intracellular targeting and clearance of oligomeric alpha-synuclein alleviates toxicity in mammalian cells
Bin Yuan et al.
NEUROSCIENCE LETTERS (2009)
Conformational Targeting of Fibrillar Polyglutamine Proteins in Live Cells Escalates Aggregation and Cytotoxicity
Erik Kvam et al.
PLOS ONE (2009)
Huntington's disease: from pathology and genetics to potential therapies
Sara Imarisio et al.
BIOCHEMICAL JOURNAL (2008)
Consequence of A immunization on the vasculature of human Alzheimers disease brain
D. Boche et al.
BRAIN (2008)
Anti-oligomeric single chain variable domain antibody differentially affects huntingtin and α-synuclein aggregates
Brent L. Nannenga et al.
FEBS LETTERS (2008)
Protein Misfolding Inside Cells: The Case of Huntingtin and Huntington's Disease
Danny A. Hatters
IUBMB LIFE (2008)
Suppression of neuropil aggregates and neurological symptoms by an intracellular antibody implicates the cytoplasmic toxicity of mutant huntingtin
Chuan-En Wang et al.
JOURNAL OF CELL BIOLOGY (2008)
An scFv intrabody against the nonamyloid component of α-synuclein reduces intracellular aggregation and toxicity
Sandra M. Lynch et al.
JOURNAL OF MOLECULAR BIOLOGY (2008)
Intrabodies binding the proline-rich domains of mutant huntingtin increase its turnover and reduce neurotoxicity
Amber L. Southwell et al.
JOURNAL OF NEUROSCIENCE (2008)
Long-term effects of Aβ42 immunisation in Alzheimer's disease:: follow-up of a randomised, placebo-controlled phase I trial
Clive Holmes et al.
LANCET (2008)
Linking Aβ and Tau in Late-Onset Alzheimer's Disease: A Dual Pathway Hypothesis
Scott A. Small et al.
NEURON (2008)
Huntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicity
Randy Singh Atwal et al.
HUMAN MOLECULAR GENETICS (2007)
Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements
Ayodeji A. Asuni et al.
JOURNAL OF NEUROSCIENCE (2007)
Isolation of a human single chain antibody fragment against oligomeric α-synuclein that inhibits aggregation and prevents α-synuclein-induced toxicity
Sharareh Emadi et al.
JOURNAL OF MOLECULAR BIOLOGY (2007)
Autoantibodies to alpha-synuclein in inherited Parkinson's disease
Katerina K. Papachroni et al.
JOURNAL OF NEUROCHEMISTRY (2007)
The first 17 amino acids of Huntingtin modulate its sub-cellular localization, aggregation and effects on calcium homeostasis
Erica Rockabrand et al.
HUMAN MOLECULAR GENETICS (2007)
Tau-mediated neurodegeneration in Alzheimer's disease and related disorders
Carlo Ballatore et al.
NATURE REVIEWS NEUROSCIENCE (2007)
Intracranial adeno-associated virus-mediated delivery of anti-pan amyloid β, amyloid β40, and amyloid β42 single-chain variable fragments attenuates plaque pathology in amyloid precursor protein mice
Yona Levites et al.
JOURNAL OF NEUROSCIENCE (2006)
Tauopathy-like abnormalities and neurologic deficits in mice immunized with neuronal tau protein
Hanna Rosenmann et al.
ARCHIVES OF NEUROLOGY (2006)
Anti-Aβ single-chain antibody delivery via adeno-associated virus for treatment of Alzheimer's disease
Ken-ichiro Fukuchi et al.
NEUROBIOLOGY OF DISEASE (2006)
Intracellular pathways of folded and misfolded amyloid precursor protein degradation
James F. Hare
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2006)
Anti-A beta(42)- and anti-A beta(40)-specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse model
Y Levites et al.
JOURNAL OF CLINICAL INVESTIGATION (2006)
Absence of behavioral abnormalities and neurodegeneration in vivo despite widespread neuronal huntingtin inclusions
EJ Slow et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Suppression of Huntington's disease pathology in Drosophila by human single-chain Fv antibodies
WJ Wolfgang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Effects of α-synuclein immunization in a mouse model of Parkinson's disease
E Masliah et al.
NEURON (2005)
A human single-chain Fv intrabody preferentially targets amino-terminal huntingtin fragments in striatal models of Huntington's disease
TW Miller et al.
NEUROBIOLOGY OF DISEASE (2005)
Effects of Aβ immunization (AN1792) on MRI measures of cerebral volume in Alzheimer disease
NC Fox et al.
NEUROLOGY (2005)
α-Synuclein targets the plasma membrane via the secretory pathway and induces toxicity in yeast
C Dixon et al.
GENETICS (2005)
β-site specific intrabodies to decrease and prevent generation of Alzheimer's Aβ peptide
P Paganetti et al.
JOURNAL OF CELL BIOLOGY (2005)
A single-chain Fv intrabody provides functional protection against the effects of mutant protein in an organotypic slice culture model of Huntington's disease
RC Murphy et al.
MOLECULAR BRAIN RESEARCH (2004)
Huntingtin bodies sequester vesicle-associated proteins by a polyproline-dependent interaction
ZH Qin et al.
JOURNAL OF NEUROSCIENCE (2004)
Development of a human light chain variable domain (VL) intracellular antibody specific for the amino terminus of huntingtin via yeast surface display
DW Colby et al.
JOURNAL OF MOLECULAR BIOLOGY (2004)
Activation of the IκB kinase complex and nuclear factor-κB contributes to mutant Huntingtin neurotoxicity
A Khoshnan et al.
JOURNAL OF NEUROSCIENCE (2004)
Aβ immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome
S Oddo et al.
NEURON (2004)
A human single-chain Fv intrabody blocks aberrant cellular effects of overexpressed α-synuclein
C Zhou et al.
MOLECULAR THERAPY (2004)
Single chain variable fragments against β-amyloid (Aβ) can inhibit Aβ aggregation and prevent Aβ-induced neurotoxicity
RT Liu et al.
BIOCHEMISTRY (2004)
Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death
M Arrasate et al.
NATURE (2004)
UCSF chimera - A visualization system for exploratory research and analysis
EF Pettersen et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2004)
Degradation of β-amyloid by proteolytic antibody light chains
SK Rangan et al.
BIOCHEMISTRY (2003)
Antibodies against β-amyloid slow cognitive decline in Alzheimer's disease
C Hock et al.
NEURON (2003)
DNA vaccination against mutant huntingtin ameliorates the HDR6/2 diabetic phenotype
TW Miller et al.
MOLECULAR THERAPY (2003)
Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
R Kayed et al.
SCIENCE (2003)
Human antibodies against amyloid β peptide:: A potential treatment for Alzheimer's disease
R Dodel et al.
ANNALS OF NEUROLOGY (2002)
Amyloid-like features of polyglutamine aggregates and their assembly kinetics
SM Chen et al.
BIOCHEMISTRY (2002)
Effects of intracellular expression of anti-huntingtin antibodies of various specificities on mutant huntingtin aggregation and toxicity
A Khoshnan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
New anti-huntingtin monoclonal antibodies: Implications for huntingtin conformation and its binding proteins
J Ko et al.
BRAIN RESEARCH BULLETIN (2001)
Human single-chain Fv intrabodies counteract in situ huntingtin aggregation in cellular models of Huntington's disease
JM Lecerf et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Conformational properties of α-synuclein in its free and lipid-associated states
D Eliezer et al.
JOURNAL OF MOLECULAR BIOLOGY (2001)
The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription
JS Steffan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Huntingtin's WW domain partners in Huntington's disease post-mortem brain fulfill genetic criteria for direct involvement in Huntington's disease pathogenesis
LA Passani et al.
HUMAN MOLECULAR GENETICS (2000)
分享论文
