期刊
REVIEWS IN MEDICAL VIROLOGY
卷 20, 期 5, 页码 265-280出版社
WILEY
DOI: 10.1002/rmv.647
关键词
-
类别
资金
- EU [LSHB-CT-2003-503410]
- Nord-Pas-de-Calais region (ArCir convention) [2004/018]
- CHRU Lille
- Comite Mixte franco-tunisien de Cooperation Universitaire (CMCU) [04/G0810, 08/G0808]
- Ministere de l'Education Nationale, de la Recherche et de la Technologie, Universite Lille 2, France
- Ministere de l'Enseignement Superieur, de la Recherche Scientifique et de la Technologie, Tunisia
Environmental factors, especially viruses, are involved in the initiation or the acceleration of type 1 diabetes (T1D) pathogenesis. Epidemiological data strongly suggest that enteroviruses, such as coxsackievirus B4 (CV-B4), can be associated with T1D. It has been demonstrated that enterovirus infections were significantly more prevalent in at risk individuals, such as siblings of diabetic patients, when they developed anti-beta-cell autoantibodies or T1D, and in recently diagnosed diabetic patients, compared with control subjects. The isolation of CV-B4 from the pancreas of diabetic patients strengthened the hypothesis of a relationship between the virus and the disease. Studies performed in vitro and in vivo in animal models helped to discover mechanisms of the infection of pancreas and other tissues, potentially able to play a role in the pathogenesis of T1D. Interestingly, it cannot be excluded that enteroviruses behave as half-devil half-angel since experimental studies suggest that, in certain conditions, these agents would be able to protect individuals against the disease. All of the plausible mechanisms by which enterovirus may be related to T1D will be reviewed here. Copyright (C) 2010 John Wiley & Sons, Ltd.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据