期刊
REVIEWS IN MEDICAL MICROBIOLOGY
卷 23, 期 3, 页码 52-57出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MRM.0b013e328353f49c
关键词
chronic inflammatory intestinal diseases; colorectal cancer; commensal bacteria metabolism; gut microflora; intestinal stem cells
类别
Human intestinal microbiota is characterized by high population density, wide diversity and complexity of interactions. Dysbiosis, both qualitative and quantitative, might have serious health consequences including an increase in the number and/or alteration of bacteria colonizing the gastrointestinal tract, which could be referred as gut microflora imbalance (GMI). GMI is frequently found in patients suffering from irritable bowel syndrome; this is the reason why some authors believe that IBS is secondary to GMI. Interestingly, GMI is also found in about 25% of Crohn's disease patients. Stimulation of inflammation by the 'dangerous bacteria', through specific activation of the intestinal immune system, seems to be the widely accepted pathogenetic hypothesis to explain such a correlation; on the contrary, some components of the intestinal microflora could also exert a protective role through immunomodulation. Stimulation of inflammation is also the main mechanism by which the gut microflora could increase the cancer risk; another alternative, but not mutually exclusive, pathogenetic hypothesis involves the regulation of proliferation/differentiation of intestinal stem cells. In this review, some interesting data regarding biomolecular alterations associated with intestinal bowel diseases will be described. We will discuss more recent findings about the relationship between GMI and intestinal chronic inflammation, pointing out the oncogenic risk related to alteration of microbiota composition. Finally, we generate an intriguing hypothesis regarding a network between gut microflora and intestinal stem cells. (C) 2012 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins
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