期刊
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
卷 11, 期 3, 页码 205-215出版社
SPRINGER
DOI: 10.1007/s11154-010-9151-3
关键词
ER stress; Insulin; Maturity-onset diabetes of the young; Neonatal diabetes; Type 1 diabetes; Unfolded protein response
资金
- The University of Chicago Diabetes Research and Training Center [DK-13914, DK-48494, DK-20595]
- Diabetes Centers R24 Seeding Collaborative Interdisciplinary Team Science in Diabetes, Endocrinology and Metabolic Diseases [DK-13914, DK-48494, DK-20595]
Over the last decade our insight into the causes of neonatal diabetes has greatly expanded. Neonatal diabetes was once considered a variant of type 1 diabetes that presented early in life. Recent advances in our understanding of this disorder have established that neonatal diabetes is not an autoimmune disease, but rather is a monogcnic form of diabetes resulting from mutations in a number of different genes encoding proteins that play a key role in the normal function of the pancreatic beta-cell. Moreover, a correct genetic diagnosis can affect treatment and clinical outcome. This is especially true for patients with mutations in the genes KCNJ11 or ABCC8 that encode the two protein subunits (Kir6.2 and SUR1, respectively) of the ATP-sensitive potassium channel. These patients can be treated with oral sulfonylurea drugs with better glycemic control and quality of life. Recently, mutations in the insulin gene (INS) itself have been identified as another cause of neonatal diabetes. In this article, we review the role of INS mutations in the pathophysiology of neonatal diabetes.
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