期刊
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
卷 9, 期 3, 页码 203-211出版社
SPRINGER
DOI: 10.1007/s11154-008-9087-z
关键词
Adiposity; Developmental origins of health and disease (DOHaD); Insulin resistance; Intrauterine programming; Maternal nutrition; Offspring
资金
- Wellcome Trust (London, UK)
- Nestle Foundation (Lausanne, Switzerland)
- International Atomic Energy Agency (Vienna, Austria)
- Department of Biotechnology (DBT), Government of India (New Delhi, India)
It is traditionally believed that genetic susceptibility and adult faulty lifestyle lead to type 2 diabetes, a chronic non-communicable disease. The Developmental Origins of Health and Disease (DOHaD) model proposes that the susceptibility to type 2 diabetes originates in the intrauterine life by environmental fetal programming, further exaggerated by rapid childhood growth, i.e. a biphasic nutritional insult. Both fetal under nutrition (sometimes manifested as low birth weight) and over nutrition (the baby of a diabetic mother) increase the risk of future diabetes. The common characteristic of these two types of babies is their high adiposity. An imbalance in nutrition seems to play an important role, and micro-nutrients seem particularly important. Normal to high maternal folate status coupled with low vitamin B-12 status predicted higher adiposity and insulin resistance in Indian babies. Thus, I-C (methyl) metabolism seems to play a key role in fetal programming. DOHaD represents a paradigm shift in the model for prevention of the chronic non-communicable diseases.
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