期刊
REVIEW OF SCIENTIFIC INSTRUMENTS
卷 83, 期 11, 页码 -出版社
AMER INST PHYSICS
DOI: 10.1063/1.4766938
关键词
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资金
- EPSRC [EP/G00224X/1]
- EU [238671]
- STFC through a PNPAS award of the RCUK MI-3 programme [GR/S85733/01]
- ERC
- ISIS Innovation Ltd.
- EPSRC [EP/G00224X/1] Funding Source: UKRI
- STFC [ST/J002895/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [GR/S85733/01, EP/G00224X/1, 1114211] Funding Source: researchfish
- Science and Technology Facilities Council [ST/J002895/1] Funding Source: researchfish
Imaging mass spectrometry is a powerful technique that allows chemical information to be correlated to a spatial coordinate on a sample. By using stigmatic ion microscopy, in conjunction with fast cameras, multiple ion masses can be imaged within a single experimental cycle. This means that fewer laser shots and acquisition cycles are required to obtain a full data set, and samples suffer less degradation as overall collection time is reduced. We present the first spatial imaging mass spectrometry results obtained with a new time-stamping detector, named the pixel imaging mass spectrometry (PImMS) sensor. The sensor is capable of storing multiple time stamps in each pixel for each time-of-flight cycle, which gives it multi-mass imaging capabilities within each pixel. A standard velocity-map ion imaging apparatus was modified to allow for microscope mode spatial imaging of a large sample area (approximately 5 x 5 mm(2)). A variety of samples were imaged using PImMS and a conventional camera to determine the specifications and possible applications of the spectrometer and the PImMS camera. (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.4766938]
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