期刊
MATERIALS
卷 8, 期 1, 页码 216-230出版社
MDPI
DOI: 10.3390/ma8010216
关键词
cholesterol; controlled delivery; doxorubicin; malignancy therapeutics; polylactide; stereocomplex micelle
类别
资金
- National Natural Science Foundation of China [51303174, 51321062, 51233004, 51390484, 51273196, 51203153]
- Scientific Development Program of Jilin Province [20140520050JH]
Nanoscale micelles as an effective drug delivery system have attracted increasing interest in malignancy therapy. The present study reported the construction of the cholesterol-enhanced doxorubicin (DOX)-loaded poly(D-lactide)-based micelle (CDM/DOX), poly(L-lactide)-based micelle (CLM/DOX), and stereocomplex micelle (CSCM/DOX) from the equimolar enantiomeric 4-armed poly(ethylene glycol)-polylactide copolymers in aqueous condition. Compared with CDM/DOX and CLM/DOX, CSCM/DOX showed the smallest hydrodynamic size of 96 +/- 4.8 nm and the slowest DOX release. The DOX-loaded micelles exhibited a weaker DOX fluorescence inside mouse renal carcinoma cells (i. e., RenCa cells) compared to free DOX center dot HCl, probably because of a slower DOX release. More importantly, all the DOX-loaded micelles, especially CSCM/DOX, exhibited the excellent antiproliferative efficacy that was equal to or even better than free DOX center dot HCl toward RenCa cells attributed to their successful internalization. Furthermore, all of the DOX-loaded micelles exhibited the satisfactory hemocompatibility compared to free DOX center dot HCl, indicating the great potential for systemic chemotherapy through intravenous injection.
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