期刊
MATERIALS
卷 8, 期 8, 页码 4733-4750出版社
MDPI
DOI: 10.3390/ma8084733
关键词
mineralized collagen; collagen; hydroxyapatite; biomineralization; self-assembly; medical device product; clinical application
类别
资金
- National Basic Research Program (973 Program) of China [2011CB606205]
- 'Twelfth Five-Year' National Science and Technology Support Program - Ministry of Science and Technology of China [2012BAI17B02]
- National Natural Science Fund - National Natural Science Foundation of China [21371106, 51402167]
This paper presents a review of the rationale for the in vitro mineralization process, preparation methods, and clinical applications of mineralized collagen. The rationale for natural mineralized collagen and the related mineralization process has been investigated for decades. Based on the understanding of natural mineralized collagen and its formation process, many attempts have been made to prepare biomimetic materials that resemble natural mineralized collagen in both composition and structure. To date, a number of bone substitute materials have been developed based on the principles of mineralized collagen, and some of them have been commercialized and approved by regulatory agencies. The clinical outcomes of mineralized collagen are of significance to advance the evaluation and improvement of related medical device products. Some representative clinical cases have been reported, and there are more clinical applications and long-term follow-ups that currently being performed by many research groups.
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