期刊
RETROVIROLOGY
卷 10, 期 -, 页码 -出版社
BMC
DOI: 10.1186/1742-4690-10-41
关键词
Cell-associated HIV RNA; Virological biomarker; HIV-1 persistence; HIV-1 reservoir; Antiretroviral therapy; HIV cure
类别
资金
- AIDS Fonds Netherlands
In most HIV-infected individuals adherent to modern antiretroviral therapy (ART), plasma viremia stays undetectable by clinical assays and therefore, additional virological markers for monitoring and predicting therapy responses and for measuring the degree of HIV persistence in patients on ART should be identified. For the above purposes, quantitation of cell-associated HIV biomarkers could provide a useful alternative to measurements of viral RNA in plasma. This review concentrates on cell-associated (CA) HIV RNA with the emphasis on its use as a virological biomarker. We discuss the significance of CA HIV RNA as a prognostic marker of disease progression in untreated patients and as an indicator of residual virus replication and the size of the dynamic viral reservoir in ART-treated patients. Potential value
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据