期刊
RETROVIROLOGY
卷 9, 期 -, 页码 -出版社
BIOMED CENTRAL LTD
DOI: 10.1186/1742-4690-9-88
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-
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资金
- NIH [AI098524, AI102822]
- program of Public Health Preparedness for Infectious Diseases of The Ohio State University
Resting CD4(+) T-cells are critical for establishing HIV-1 reservoirs. It has been known for over two decades that resting CD4(+) T-cells are refractory to HIV-1 infection, but the underlying mechanisms are not fully understood. Compared with activated CD4(+) T-cells that support HIV-1 infection, resting CD4(+) T-cells have lower levels of dNTPs, which limit HIV-1 reverse transcription. The dNTPase SAMHD1 has been identified as an HIV-1 restriction factor in non-cycling myeloid cells. Two recent studies revealed that SAMHD1 restricts HIV-1 infection in resting CD4(+) T-cells, suggesting a common mechanism of HIV-1 restriction in non-cycling cells that may contribute to viral immunopathogenesis.
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