期刊
RETROVIROLOGY
卷 8, 期 -, 页码 -出版社
BIOMED CENTRAL LTD
DOI: 10.1186/1742-4690-8-91
关键词
Aicardi-Gouti?e?res syndrome; myocarditis; Trex1; reverse transcriptase inhibitors
类别
资金
- NIH [R01AI041570]
- Lupus Research Institute
- United States - Israel Binational Foundation (BSF)
Background: Both Aicardi-Goutieres syndrome, a Mendelian mimic of congenital infection, and the autoimmune disease systemic lupus erythematosus can result from mutations in the gene encoding the enzyme Trex1. In mice, the absence of Trex1 causes severe myocarditis. The enzyme is thought to degrade endogenous retroelements, thus linking them to autoimmune disease. However, inhibition of reverse transcription by the inhibitor zidovudine (AZT) did not ameliorate the disease, weakening the link to retroelements. Findings: Here, we show that two other FDA-approved drugs that inhibit reverse transcriptase can ameliorate the myocarditis in Trex1-null mouse. Conclusions: The result suggests that retroelements contribute to this hereditary form of autoimmunity, and that treatment with retroelement inhibitors might ameliorate Aicardi-Goutieres syndrome in humans.
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