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Characterization of the Molecular Determinants of Primary HIV-1 Vpr Proteins: Impact of the Q65R and R77Q Substitutions on Vpr Functions
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RETROVIROLOGY (2009)
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AIDS RESEARCH AND HUMAN RETROVIRUSES (2008)
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Vpr14-88-Apobec3G Fusion Protein Is Efficiently Incorporated into Vif-Positive HIV-1 Particles and Inhibits Viral Infection
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Akt inhibitors as an HIV-1 infected macrophage-specific anti-viral therapy
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Direct Vpr-Vpr Interaction in Cells monitored by two Photon Fluorescence Correlation Spectroscopy and Fluorescence Lifetime Imaging
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Lentiviral Vpx accessory factor targets VprBP/DCAF1 substrate adaptor for cullin 4 E3 ubiquitin ligase to enable macrophage infection
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Human immunodeficiency virus type 1 Vpr inhibits axonal outgrowth through induction of mitochondrial dysfunction
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Localization of HIV-1 Vpr to the nuclear envelope: Impact on Vpr functions and virus replication in macrophages
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Evidence for direct involvement of the capsid protein in HIV infection of nondividing cells
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DDB1 and Cu14A are required for human immunodeficiency virus type 1 vpr-induced G2 arrest
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JOURNAL OF VIROLOGY (2007)
The HIV1 protein vpr acts to promote G2 cell cycle arrest by engaging a DDB1 and Cullin4A-containing ubiquitin ligase complex using VprBP/DCAF1 as an adaptor
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HIV-1 Vpr-mediated G2 arrest involves the DDB1-CUL4AVPRBP E3 ubiquitin ligase
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Dendritic cells infected with vpr-positive human immunodeficiency virus type 1 induce CD8+ T-cell apoptosis via upregulation of tumor necrosis factor alpha
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JOURNAL OF VIROLOGY (2007)
HIV-1 DNA Flap formation promotes uncoating of the pre-integration complex at the nuclear pore
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HIV-I Vpr activates the G2 checkpoint through manipulation of the ubiquitin proteasome system
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Novel nuclear import of Vpr promoted by importin α is crucial for human immunodeficiency virus type 1 replication in macrophages
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JOURNAL OF VIROLOGY (2007)
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MOLECULAR MEDICINE (2007)
HIV-1 Vpr causes neuronal apoptosis and in vivo neurodegeneration
Gareth J. Jones et al.
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HIV-1 Vpr function is mediated by interaction with the damage-specific DNA-binding protein DDB1
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Human immunodeficiency virus (HIV) type 1 Vpr induces differential regulation of T cell costimulatory molecules: Direct effect of Vpr on T cell activation and immune function
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HIV1 Vpr arrests the cell cycle by recruiting DCAF1/VprBP, a receptor of the Cul4-DDB1 ubiquitin ligase
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Poly (propyleneimine) dendrimer based nanocontainers for targeting of efavirenz to human monocytes/macrophages in vitro
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Poly (propyleneimine) dendrimer based nanocontainers for targeting of efavirenz to human inonocytes/macrophages in vitro (vol 15, pg 89, 2007)
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Human immunodeficiency virus type 1 Vpr induces DNA replication stress in vitro and in vivo
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HIV-1 genes vpr and nef synergistically damage podocytes, leading to glomerulosclerosis
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The HIV-1 Vpr and glucocorticoid receptor complex is a gain-of-function interaction that prevents the nuclear localization of PARP-1
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Synthetic vpr protein activates activator protein-1, c-jun N-terminal kinase, and NF-κB and stimulates HIV-1 transcription in promonocytic cells and primary macrophages
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Fibroblast growth factor-2 increases the renal recruitment and attachment of HIV-infected mononuclear cells to renal tubular epithelial cells
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Critical implication of the (70-96) domain of human immunodeficiency virus type 1 Vpr protein in apoptosis of primary rat cortical and striatal neurons
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Human immunodeficiency virus type 1 Vpr interacts with antiapoptotic mitochondrial protein HAX-1
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HIV-1 viral protein-R (VPR) protects against lethal superantigen challenge while maintaining homeostatic T cell levels in vivo
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MOLECULAR THERAPY (2005)
Expression of HIV-1 genes in podocytes alone can lead to the full spectrum of HIV-1-associated nephropathy
JY Zhong et al.
KIDNEY INTERNATIONAL (2005)
Human immunodeficiency virus type 1 Vpr impairs dendritic cell maturation and T-Cell activation: Implications for viral immune escape
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HIV-1 tat protein concomitantly down-regulates apical caspase-10 and up-regulates c-FLIP in lymphoid T cells: A potential molecular mechanism to escape TRAIL cytotoxicity
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Importin α transports CaMKIV to the nucleus without utilizing importin β
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EMBO JOURNAL (2005)
Importin-α promotes passage through the nuclear pore complex of human immunodeficiency virus type 1 Vpr
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HIV-1 Vpr inhibits the maturation and activation of macrophages and dendritic cells in vitro
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INTERNATIONAL IMMUNOLOGY (2005)
Focal glomerulosclerosis in proviral and c-fms transgenic mice links Vpr expression to HIV-associated nephropathy
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High-affinity interaction between HIV-1 Vpr and specific sequences that span the C/EBP and adjacent NF-κB sites within the HIV-1 LTR correlate with HIV-1-associated dementia
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Morphine modulates HIV-1 gp160-induced murine macrophage and human monocyte apoptosis by disparate ways
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Nuclear localization of Vpr is crucial for the efficient replication of HIV-1 in primary CD4+ T cells
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Heat-shock protein 70 exerts opposing effects on Vpr-dependent and Vpr-independent HIV-1 replication in macrophages
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BLOOD (2004)
Heat shock protein 70 protects cells from cell cycle arrest and apoptosis induced by human immunodeficiency virus type 1 viral protein R
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Simian immunodeficiency virus Vpr/Vpx proteins kill bystander noninfected CD4+T-lymphocytes by induction of apoptosis
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AMERICAN JOURNAL OF PATHOLOGY (2004)
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Species-specific exclusion of APOBEC3G from HIV-1 virions by Vif
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CELL (2003)
NMR structure of the HIV-1 regulatory protein VPR
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HIV-1 Vpr binding to HIV-1 LTR C/EBP cis-acting elements and adjacent regions is sequence-specific
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Ethanol strongly potentiates apoptosis induced by HIV-1 proteins in primary human brain microvascular endothelial cells
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Carboxyl terminus of hVIP/mov34 is critical for HIV-1-Vpr interaction and glucocorticoid-mediated signaling
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Docking of HIV-1 Vpr to the nuclear envelope is mediated by the interaction with the nucleoporin hCG1
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Transcription factor TFIIH components enhance the GR coactivator activity but not the cell cycle-arresting activity of the human immunodeficiency virus type-1 protein Vpr
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)
Human immunodeficiency virus type 1 (HIV-1) accessory protein Vpr induces transcription of the HIV-1 and glucocorticoid-responsive promoters by binding directly to p300/CBP coactivators
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Vpr- and Nef-dependent induction of RANTES/CCL5 in microglial cells
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Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein
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Inclusion of Vpr accessory gene in a plasmid vaccine cocktail markedly reduces Nef vaccine effectiveness in vivo resulting in CD4 cell loss and increased viral loads in rhesus macaques
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Adenovirus encoding HIV-1 Vpr activates caspase 9 and induces apoptotic cell death in both p53 positive and negative human tumor cell lines
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Lentiviral expression of HIV-1 vpr induces apoptosis in human neurons
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Phosphorylation of Vpr regulates HIV type 1 nuclear import and macrophage infection
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HIV-1 viral protein R compromises cellular immune function in vivo
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CNS invasion by CD14+/CD16+peripheral blood-derived monocytes in HIV dementia:: perivascular accumulation and reservoir of HIV infection
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HIV-1 Vpr enhances viral burden by facilitating infection of tissue macrophages but not nondividing CD4+ T cells
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HIV-1 Vpr transactivates LTR-directed expression through sequences present within-278 to-176 and increases virus replication in vitro
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T cell apoptosis causes peripheral T cell depletion in mice transgenic far the HIV-1 vpr gene
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JOURNAL OF EXPERIMENTAL MEDICINE (2001)
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JOURNAL OF VIROLOGY (2001)
Macrophage are the principal reservoir and sustain high virus loads in rhesus macaques after the depletion of CD4+ T cells by a highly pathogenic simian immunodeficiency virus/HIV type 1 chimera (SHIV):: Implications for HIV-1 infections of humans
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Glucocorticoids suppress human immunodeficiency virus type-1 long terminal repeat activity in a cell type-specific, glucocorticoid receptor-mediated fashion: direct protective effects at variance with clinical phenomenology
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Cooperative interaction between HIV-1 regulatory proteins Tat and Vpr modulates transcription of the viral genome
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Functional role of residues corresponding to helical domain II (amino acids 35 to 46) of human immunodeficiency virus type 1 Vpr
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Induction of apoptosis by the Vpr protein of human immunodeficiency virus type 1 occurs independently of G2 arrest of the cell cycle
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Human immunodeficiency virus type 1 Vpr induces apoptosis in human neuronal cells
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Heat-shock protein 70 can replace viral protein R of HIV-1 during nuclear import of the viral preintegration complex
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Two putative α-helical domains of human immunodeficiency virus type 1 Vpr mediate nuclear localization by at least two mechanisms
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Regulation of cell cycle and apoptosis by human immunodeficiency virus type 1 Vpr
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Intranuclear binding by the HIV-1 regulatory protein VPR is dependent on cytosolic factors
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)
Human immunodeficiency virus type 1 Vpr induces apoptosis through caspase activation
SA Stewart et al.
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Activation of transcription factors NF-κB and NF-IL-6 by human immunodeficiency virus type 1 protein R (Vpr) induces interieukin-8 expression
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Could Nef and Vpr proteins contribute to disease progression by promoting depletion of bystander cells and prolonged survival of HIV-infected cells?
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Human immunodeficiency virus type 1 Vpr contains two leucine-rich helices that mediate glucocorticoid receptor coactivation independently of its effects on G(2) cell cycle arrest
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