期刊
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
卷 31, 期 5, 页码 949-958出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/IAE.0b013e3181f441f6
关键词
microperimetry; SLO infrared imaging; Stargardt disease; fundus autofluorescence imaging
资金
- Foundation Fighting Blindness, Owing Mills, Maryland
- Grant Healthcare Foundation, Chicago, Illinois
- National Institutes of Health [EY01792]
- Research to Prevent Blindness
Purpose: To correlate the degree of functional loss with structural changes in patients with Stargardt disease. Methods: Eighteen eyes of 10 patients with Stargardt disease were studied. Scanning laser ophthalmoscope infrared images were compared with corresponding spectral-domain optical coherence tomography scans. Additionally, scanning laser ophthalmoscope microperimetry was performed, and results were superimposed on scanning laser ophthalmoscope infrared images and in selected cases on fundus autofluorescence images. Results: Seventeen of 18 eyes showed a distinct hyporeflective foveal and/or perifoveal area with distinct borders on scanning laser ophthalmoscope infrared images, which was less evident on funduscopy and incompletely depicted in fundus autofluorescence images. This hyporeflective zone corresponded to areas of significantly elevated psychophysical thresholds on microperimetry testing, in addition to thinning of the retinal pigment epithelium and disorganization or loss of the photoreceptor cell inner segment-outer segment junction and external-limiting membrane on spectral-domain optical coherence tomography. Conclusion: Scanning laser ophthalmoscope infrared fundus images are useful for depicting retinal structural changes in patients with Stargardt disease. A spectral-domain optical coherence tomography/scanning laser ophthalmoscope microperimetry device allows for a direct correlation of structural abnormalities with functional defects that will likely be applicable for the determination of retinal areas for potential improvement of retinal function in these patients during future clinical trials and for the monitoring of the diseases' natural history. RETINA 31:949-958, 2011
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