期刊
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
卷 30, 期 10, 页码 1726-1733出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/IAE.0b013e3181dde629
关键词
X-linked retinitis pigmentosa; tapetal-like reflex; microperimetry; fundus autofluorescence; spectral domain OCT
资金
- Foundation Fighting Blindness, Owings Mills, MD
- Grant Healthcare Foundation, Lake Forest, IL
- National Institutes of Health [EYO1792]
- Research to Prevent Blindness
Purpose: The purpose of this study was to identify the functional and structural characteristics in three female obligate carriers of X-linked retinitis pigmentosa from the same family by using spectral domain optical coherence tomography, fundus autofluorescence, and microperimetry. Methods: Three female obligate carriers with a tapetal-like reflex, 21, 49, and 57 years of age, from a single family of X-linked retinitis pigmentosa that was seen in the ophthalmology department at the University of Illinois at Chicago, were enrolled in the study. All carriers underwent a complete ophthalmic examination. Spectral domain optical coherence tomography measurements, a macular microperimetry examination, and fundus autofluorescence testing were performed. Results: The spectral domain optical coherence tomography examination in all three carriers showed a normal retinal microstructure and thickness. Microperimeter testing showed subnormal retinal sensitivity in the areas of the tapetal-like reflex. Fundus autofluorescence examination showed the presence of speckled areas of enhanced autofluorescence. Conclusion: Our study demonstrates that the carriers of X-linked retinitis pigmentosa with a tapetal-like reflex can show an enhanced reflectance on infrared images, abnormal autofluorescence properties, elevated retinal thresholds, and a normal retinal morphology within the posterior pole on spectral domain optical coherence tomography testing. RETINA 30:1726-1733, 2010
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