期刊
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
卷 29, 期 5, 页码 618-626出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/IAE.0b013e31819a988b
关键词
adolescent; children; Type 2 diabetes mellitus; diabetic neuropathy; diabetic retinopathy; retina; vascular health; multifocal electroretinogram; optical coherence tomography; retinal vessel analysis
资金
- Prevent Blindness America (MES)
- National Eye Institute [EY02271, T32 TY07043]
Purpose: The eye provides a unique window into the neural and vascular health of a patient with diabetes. The present study is the first of its kind to examine the neural retinal function, structure, and retinal vascular health in adolescents with Type 2 diabetes. Methods: Focal neural responses from 103 discrete retinal regions of the eye were tested using multifocal electroretinography. Optical coherence tomography was utilized to measure retinal thickness. Digital fundus photographs were examined for the presence of retinopathy and to measure vascular caliber using retinal vessel analysis. Fifteen adolescents diagnosed with Type 2 diabetes, aged 13 to 21 years with a mean diabetes duration of 2.1 +/- 1.3 years, were tested. Twenty-six age-matched control subjects were also tested. Results: Multifocal electroretinograms of the Type 2 diabetic group were significantly (P = 0.03) delayed by 0.49 milliseconds. The diabetic group also showed significant (both; P <= 0.03) retinal thinning (10.3 mu m) and significant venular dilation (16.2 mu m). Conclusion: The present study shows early indications of focal retinal neuropathy, retinal thinning, and venular dilation in adolescents with Type 2 diabetes. Early detection of functional and structural changes will hopefully aid in the prevention of permanent damage or further functional loss. RETINA 29:618-626, 2009
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据