期刊
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
卷 189, 期 2, 页码 324-328出版社
ELSEVIER
DOI: 10.1016/j.resp.2013.06.026
关键词
SUDEP; Epilepsy; Respiration; Sodium channel
资金
- National Institutes of Health [R01 NS25704, K01 NS062862]
- McKnight Foundation
Sudden unexpected deaths in epilepsy (SUDEP) occur at an alarming higher rate in patients with Dravet syndrome (DS) than in patients with most other forms of epilepsy. DS is a severe infantile-onset epilepsy caused by a heterozygote loss-of-function mutation in SCN1A, which encodes the voltage-gated-sodium channel Nay 1.1. The mechanisms leading to SUDEP in DS or other epilepsies are not completely understood. Understanding the pathophysiological mechanisms of SUDEP, common to most epilepsies and those specific to DS, may pave the way toward the discovery of effective preventive strategies for these epilepsy-related tragic events. (C) 2013 Elsevier B.V. All rights reserved.
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