期刊
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
卷 181, 期 1, 页码 79-87出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.resp.2012.01.008
关键词
Peripheral chemoreceptor; Central chemoreceptor; Respiratory control; Hypercapnic-hypoxic interaction; Vagotomy
资金
- National Institutes of Health [HL067966, HL093225, RR028241]
- American Heart Association
A negative influence of central chemosensitivity on peripheral chemoreflex response has been demonstrated recently in a decerebrate-vagotomized rat preparation in situ with separate carotid body and brainstem perfusions. Here, we report similar negative influences of hypercapnia on the hypoxic respiratory response in anesthetized, spontaneously breathing rats before and after vagotomy and anesthetized, artificially ventilated rats after vagotomy. Baseline breathing patterns and responsiveness to hypercapnia and hypoxia varied widely between the three respiratory modes. Despite this, the responses in inspiratory amplitude and expiratory duration (and hence respiratory frequency and neural ventilation) to hypoxia varied inversely with the background CO2 level in all three groups. Results demonstrate a hypoadditive hypercapnic-hypoxic interaction in vivo that resembles the hypoadditive central-peripheral chemoreceptor interaction in situ for these respiratory variables in the rat, regardless of differences in vagal feedback, body temperature and ventilation method. These observations stand in contrast to previous reports of hyperadditive peripheral-central chemoreceptor interaction. (C) 2012 Elsevier B.V. All rights reserved.
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