期刊
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
卷 182, 期 2-3, 页码 81-87出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.resp.2012.05.004
关键词
Asthma; Allergy; Immunology; Cytokines; Exercise; Training
资金
- Fundacao de Amparo a Pesquisa de Sao Paulo (FAPESP) [050044-13-1, 0658259-6]
- Laboratorio de Investigacao Medica (LIM) do Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo
- Conselho Nacional de Pesquisa (CNPq) grants [309247/2007-1]
We evaluated the effects of aerobic exercise (AE) on airway inflammation, exhaled nitric oxide levels (ENO), airway remodeling, and the expression of Thl, Th2 and regulatory cytokines in a guinea pig asthma model. Animals were divided into 4 groups: non-trained and non-sensitized (C), non-sensitized and AE (AE), ovalbumin-sensitized and non-trained (OVA), and OVA-sensitized and AE (OVA + AE). OVA inhalation was performed for 8 weeks, and AE was conducted for 6 weeks beginning in the 3rd week of OVA sensitization. Compared to the other groups, the OVA + AE group had a reduced density of eosinophils and lymphocytes, reduced expression of interleukin (IL)-4 and IL-13 and an increase in epithelium thickness (p < 0.05). AE did not modify airway remodeling or ENO in the sensitized groups (p > 0.05). Neither OVA nor AE resulted in differences in the expression of IL-2, IFN-gamma, IL-10 or IL1-ra. Our results show that AE reduces the expression of Th2 cytokines and allergic airway inflammation and induces epithelium remodeling in sensitized guinea pigs. (c) 2012 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据