期刊
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
卷 174, 期 3, 页码 175-181出版社
ELSEVIER
DOI: 10.1016/j.resp.2010.08.004
关键词
Erythropoiesis; Pulmonary vasoconstriction; Hypoxia; Carotid Body; ROS
资金
- NIH [R01CA123067-04]
Oxygen is necessary for the survival of mammalian cells. In order to maintain adequate cellular oxygenation, mammals have evolved multiple acute and long-term adaptive responses to hypoxia. These include hypoxic increases in erythropoiesis, pulmonary vasoconstriction and carotid body neurosecretion. Collectively, these responses help maintain oxygen homeostasis as oxygen levels remain scarce. There are multiple effectors proposed to underlie these diverse responses to hypoxia including PHD2, AMPK, NADPH oxidases, and mitochondria! complex III. Here I propose a model wherein complex III is integral to oxygen sensing in regulating diverse response to hypoxia. (C) 2010 Elsevier B.V. All rights reserved.
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