期刊
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
卷 173, 期 3, 页码 256-263出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.resp.2010.03.006
关键词
Medullary serotonin; pH/CO2; Respiratory chemoreceptor
资金
- NHLBI [HL097033]
- NIH [HD36379, HD052772]
- VAMC
- Bumpus Foundation
Much progress has been made in our understanding of central chemoreception since the seminal experiments of Fend, Loeschcke, Mitchell and others, including identification of new brainstem regions and specific neuron types that may serve as central sensors of CO2/pH. In this review, we discuss key attributes, or minimal requirements a neuron/cell must possess to be defined as a central respiratory chemoreceptor, and summarize how well each of the various candidates fulfill these minimal criteria-especially the presence of intrinsic chemosensitivity. We then discuss some of the in vitro and in vivo evidence in support of the conclusion that medullary serotonin (5-HT) neurons are central chemoreceptors. We also provide an additional hypothesis that chemosensitive medullary 5-HT neurons are poised to integrate multiple synaptic inputs from various other sources thought to influence ventilation. Finally, we discuss open questions and future studies that may aid in continuing our advances in understanding central chemoreception. (C) 2010 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据