期刊
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
卷 171, 期 3, 页码 218-224出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.resp.2010.03.017
关键词
Diaphragm pacing; Electrical stimulation; Intercostal muscles
资金
- NINDS NIH HHS [R01 NS064157-02, R01 NS064157, R01 NS064157-01A1] Funding Source: Medline
High frequency spinal cord stimulation (HF-SCS) is a novel and more physiologic method of inspiratory muscle activation which involves stimulation of spinal cord pathways. In the present study, we determined if activation of the inspiratory intercostal muscles alone by this technique could be utilized to maintain artificial ventilation. In 7 anesthetized dogs, following C2 spinal cord section and bilateral phrenicotomy, trains of electrical stimulation (12 times/min) were applied at the T2 level. Eucapnea was maintained during an initial 5.5 h period of continuous stimulation. During a subsequent 0.5 h period, stimulus parameters were increased to induce hyperventilation resulting in a sustained fall in end-tidal P(CO2), to 29.3 +/- 0.4 mm Hg. Single motor unit peak firing frequencies of the intercostal muscles during HF-SCS were similar to those occurring during spontaneous breathing. This technique holds promise as a method to restore ventilation in ventilator-dependent tetraplegics who do not have adequate phrenic nerve function for diaphragm pacing. (C) 2010 Elsevier By. All rights reserved.
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