期刊
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
卷 165, 期 1, 页码 1-8出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.resp.2008.10.007
关键词
Lateral parabrachial nucleus; Hypoxia; Respiratory control
资金
- National Institutes of Health [HL067966, HL072849, HL079503]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL072849, R01HL067966, R01HL079503] Funding Source: NIH RePORTER
Acute hypoxia elicits complex time-dependent responses including rapid augmentation of inspiratory drive, shortening of inspiratory and expiratory durations (T-I, T-E), and short-term potentiation and depression. The central pathways mediating these varied effects are largely unknown. Here, we show that the lateral parabrachial nucleus (LPBN) of the dorsolateral polls specifically mediates T-E-shortening during hypoxia and not other hypoxic response components. Twelve urethane-anesthetized and vagotomized adult Sprague-Dawley rats were exposed to 1-min poikilocapnic hypoxia before and after unilateral kainic acid or bilateral electrolytic lesioning of the LPBN. Bilateral lesions resulted in a significant increase in baseline T-E under hyperoxia. After unilateral or bilateral lesions, the decrease in T-E during hypoxia was markedly attenuated without appreciable changes in all other hypoxic response components. These findings add to the mounting evidence that the central processing of peripheral chemoafferent inputs is segregated into parallel integrator and differentiator (low-pass and high-pass filter) pathways that separately modulate inspiratory drive, T-I, T-E and resultant short-term potentiation and depression. (C) 2008 Elsevier B.V. All rights reserved.
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