期刊
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
卷 166, 期 2, 页码 95-101出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.resp.2009.02.009
关键词
Pharyngeal muscles; Tissue pressure; Pharyngeal patency
We examined the influence of pharyngeal dilator muscle activity on upper airway extraluminal tissue pressure. (ETP) distribution and upper airway patency. We studied seven anaesthetised, supine, spontaneously breathing NZ white rabbits. ETP was measured via pressure transducer tipped catheters in lateral (ETP(lat)) and anterior (ETP(ant)) pharyngeal wall tissues. Airflow (V) and tracheal pressure (P) were monitored and upper airway resistance (RUA) calculated. Genioglossus (GG) or bilateral sternohyoid (SH) muscles were electrically stimulated. Tongue protrusion (TP) during GG stimulation was measured. With GG stimulation, RUA decreased to 57.8 +/- 10.9% (mean +/- S.E.M.) of baseline and TP increased to 4.8 +/- 0.5 mm (both p < 0.05), but ETP(lat) (2.6 +/- 1.5 cm H(2)O) and ETP(ant) (1.4 +/- 0.8 cm H(2)O) were unchanged. SH stimulation reduced RUA to 53.6 +/- 6.8%, and ETP(lat) fell by 1.0 +/- 0.4 cm H(2)O (both p < 0.05). ErP(ant) was unchanged. GG muscle contraction decreased RUA without altering ETP, whereas SH contraction altered RUA and ETP(lat) but not ETP(ant). Contraction of the upper airway dilator muscles results in improvements in upper airway patency associated with changes in peri-pharyngeal tissue pressure. Crown Copyright (C) 2009 Published by Elsevier B.V. All rights reserved.
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