期刊
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
卷 163, 期 1-3, 页码 214-221出版社
ELSEVIER
DOI: 10.1016/j.resp.2008.05.013
关键词
Pulmonary airway closure; Liquid lining; Surface tension
资金
- Medical Research Council [G0701918] Funding Source: researchfish
- Medical Research Council [G0701918] Funding Source: Medline
- MRC [G0701918] Funding Source: UKRI
We describe how surface-tension-driven instabilities of the lung's liquid lining may lead to pulmonary airway closure via the formation of liquid bridges that occlude the airway lumen. Using simple theoretical models, we demonstrate that this process may occur via a purely fluid-mechanical film collapse or through a coupled, fluid-elastic compliant collapse mechanism. Both mechanisms can lead to airway closure in times comparable with the breathing cycle, suggesting that surface tension is the primary mechanical effect responsible for the closure observed in peripheral regions of the human lungs. We conclude by discussing the influence of additional effects not included in the simple models, such as gravity, the presence of pulmonary surfactant, respiratory flow and wall motion, the airways' geometry, and the mechanical structure of the airway walls. (C) 2008 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据