期刊
RESPIRATORY MEDICINE
卷 108, 期 11, 页码 1713-1722出版社
W B SAUNDERS CO LTD
DOI: 10.1016/j.rmed.2014.09.001
关键词
Community-acquired pneumonia; Asthma; Respiratory infections
资金
- Ciberes [CB06/06/0028]
- Ciberes es una iniciativa del ISCIII [2009SGR911]
- IDIBAPS
- Proyecto Integrado de Investigacion (PII) Infecciones Respiratorias SEPAR
Background: Limited information is available about clinical outcomes and microbiology of community-acquired pneumonia in asthma. Methods: We prospectively studied 4079 CAP patients over a 12-years period and found 139 (3.4%) asthmatic patients. Results: Asthmatics showed younger age (57 +/- 19 vs. 66 +/- 19 years), less males (32% vs. 68%) and less active smokers (15% vs. 25%). Moreover, they had used more frequently inhaled corticosteroids (ICs, 53% vs. 17%, p < 0.001) and antibiotics (32% vs. 24%, p = 0.041). In comparison with non asthma-CAP, asthmatics showed at admission more pleuritic pain and dyspnoea but less severe pneumonia (PSI, CURB-65, PaO2/F1O2 ratio; p < 0.05). No differences were observed in CAP microbiology, being Streptococcus pneumoniae the most frequent isolate. Clinical outcomes in asthmatic patients were similar to the general population (mortality, mechanical ventilation, etc.) but with a shorter median length of stay (6 [3; 9] vs. 7 [4; 10] days, p = 0.023). The chronic use of ICs did not influence clinical presentation and outcomes among asthmatic patients. Conclusions: Asthmatics were younger and showed similar clinical presentation. Consistently with PSI, asthmatics showed similar outcomes than the general population. The microbial aetiology of CAP in asthma did not differ from the general population and antibiotic therapy should follow current guidelines. (C) 2014 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据