期刊
RESPIRATORY MEDICINE
卷 105, 期 11, 页码 1691-1695出版社
W B SAUNDERS CO LTD
DOI: 10.1016/j.rmed.2011.07.011
关键词
Gastroesophageal reflux; Chronic cough; Cigarette smoking; Sputum lipid index; Smokers inclusions
资金
- Ontario Thoracic Society
- Ontario Ministry of Health
- Canadian Institutes for Health Research
- Father Sean O'Sullivan Research Centre of St Joseph's Healthcare
- Canada Research Chair in Airway Inflammometry
We studied the effect of tobacco smoking on macrophage lipid index and macrophage smokers inclusions in induced sputum in 256 patients (143 non-smokers, 81 ex-smokers and 32 current smokers). Lipid index was, using the Oil red 0 stain, the sum of the lipid staining droplet score (range 0-4) in 100 macrophages. Smokers inclusions were assessed using Wright's stain and graded as none, few, moderate or many. Lipid index was significantly higher in current smokers (112.5, SD 58.5 units) than ex-smokers (29.2, SD 42.8 units) or non-smokers (13.4, SD 121.7). Smokers inclusions were present in all current smokers but only in 2 nonsmokers. The mean smoking history of current smokers with few macrophage inclusions was 15.0 (SD 11.2), moderate 21.6 (SD 15.7), and many 30.0 (SD 21.9) pack years. There was a significant difference between the length of time ex-smokers had quit smoking if they had no or few smokers inclusions (mean 17.6 (SD 11.2) years) compared to those with moderate or many smokers inclusions (mean 2.8 (SD 5.8) years) (p = 0.01). Lipid index was significantly correlated with smokers inclusions (r = 0.72, p < 0.01). We conclude that smoker's inclusions within sputum macrophages is a reliable indicator of cigarette smoking and that the sputum lipid index cannot be used as an assessment of oropharyngeal reflux in cigarette smokers. (C) 2011 Elsevier Ltd. All rights reserved.
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