期刊
RESPIRATORY MEDICINE
卷 102, 期 8, 页码 1173-1181出版社
W B SAUNDERS CO LTD
DOI: 10.1016/j.rmed.2008.02.020
关键词
airway smooth muscle; contraction; proliferation; asthma
Airway smooth muscle (ASM) plays a key rote in bronchomotor tone, as well as in structural remodeling of the bronchial wall. Therefore, ASM contraction and proliferation significantly participate in the development and progression of asthma. Many contractile agonists also behave as mitogenic stimuli, thus contributing to frame a hyperresponsive and hyperplastic ASM phenotype. In this review, the molecular mechanisms and signaling pathways involved in excitation-contraction coupling and ASM cell growth will be outlined. Indeed, the recent advances in understanding the basic aspects of ASM biology are disclosing important cellular targets, currently explored for the implementation of new, more effective anti-asthma therapies. (C) 2008 Published by Elsevier Ltd.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据