期刊
RESPIRATION
卷 81, 期 6, 页码 469-475出版社
KARGER
DOI: 10.1159/000322008
关键词
Vitamin D; Asthma; Lung function; FEV1; IgE
资金
- Education Ministry of China [NCET 2006-0156]
- Natural Sciences Foundation of China [30470767]
- NIH [1R01 NS062879-01A2]
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS062879] Funding Source: NIH RePORTER
Background: Vitamin D deficiency has been associated with markers for allergy and asthma severity in children with asthma. However, its association with Chinese adult asthmatics has not been studied. Objective: To examine whether vitamin D status is associated with lung function and total serum IgE in Chinese adults with newly diagnosed asthma. Methods: We conducted a cross-sectional study including 435 Chinese patients aged >18 years with newly diagnosed asthma. Vitamin D status was assessed by measuring serum 25 hydroxyvitamin D (25OHD) concentrations. The primary outcomes included airflow limitation, as measured by the forced expiratory volume in 1 s (FEV1), FEV1 % predicted, and FEV1/forced vital capacity (FVC), and serum total IgE concentration. Results: Vitamin D deficiency was prevalent in Chinese adults with asthma, with 88.9% of the subjects having 25OHD <50 nmol/l. Serum 25OHD concentration was positively correlated with FEV1 % predicted (p = 0.02, r = 0.12). After adjusting for age, sex, body mass index, smoking, month of blood collection, and symptom duration, we found significant positive associations between 25OHD concentrations and FEV1 (in liters), FEV1 % predicted, and FEV1/FVC (p for trend < 0.05 for all). The adjusted odds ratios for the highest versus the lowest 25OHD quartile were 0.50 (0.26-0.96) for FEV1 <75% predicted and 0.44 (0.20-0.95) for FEV1/FVC% <0.75. There was no significant association between 25OHD concentrations and total IgE. Conclusions: Vitamin D deficiency was highly prevalent in Chinese asthma patients, and vitamin D status was associated with lung function. Copyright (C) 2010 S. Karger AG, Basel
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