Mild and efficient oxidation of 2-pyrazolines and isoxazolines by trans-3,5-dihydroperoxy-3,5-dimethyl-1,2-dioxalane-NH4Cl-HOAc in water-MeCN

An efficient method has been developed for oxidative aromatization of 2-pyrazolines and isoxazolines into their corresponding 2-pyrazoles and isoxazoles under mild conditions. In this method, trans-3,5-dihydroperoxy-3,5-dimethyl-1,2-dioxalane-NH4Cl-HOAc was used as a novel and effective oxidant in water-MeCN at room temperature with good yields.