期刊
RESEARCH IN VETERINARY SCIENCE
卷 94, 期 3, 页码 590-595出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.rvsc.2012.10.009
关键词
Hydrogen sulfide; Sodium hydrogen sulfide; DL-propargylglycine; LPS; Cystathionine-gamma-lyase; Rat
资金
- National Natural Science Foundation of China [30560113]
- Yunnan Provincial Program for Introducing High-level Scientists [2009CI125]
- Natural Science Foundation of Yunnan Province [2008CD133]
- Technology system Construction of swine industry in modern agriculture of Yunnan Province
- Program for Innovative Research Team (in Science and Technology) in University of Yunnan Province
Background: Hydrogen sulfide (H2S) is a naturally occurring gaseous transmitter and may play important roles in normal physiology and liver disease. Aims: To investigate the relationships between the formation of liver H2S and liver damage in endotoxemic rats caused by lipopolysaccharide (LPS). Methods: Male SD rats were sacrificed to acute endotoxemia and pretreated with H2S donor sodium hydrogen sulfide (NaHS) or H2S inhibitor DL-propargylglycine (PAG). Liver H2S concentration, liver cystathionine-gamma-lyase (CSE) mRNA, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) level, liver histopathological alteration in different time after treatment were determined. Results: Endotoxemia resulted in an increase in serum levels of ALT and AST. In the liver, endotoxemia induced a significant increase in the H2S concentration, and in the expression of the H2S-synthesizing enzymes CSE. Pretreatment with NaHS promoted the increase the liver H2S concentration and aggravated the LPS-induced liver damage, However, administration of PAG abolished the increase the liver H2S concentration and reduced the liver injury caused by endotoxemia. Conclusions: These findings support the view that an enhanced formation of H2S contributes to the liver injury in endotoxemia. We propose that inhibition of H2S synthesis may be a useful the rapeutic strategy against the liver injury associated with endotoxemia. (C) 2012 Elsevier Ltd. All rights reserved.
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