期刊
RESEARCH IN VETERINARY SCIENCE
卷 88, 期 1, 页码 44-49出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.rvsc.2009.05.022
关键词
Vaccination; Bovine tuberculosis; Mycobacterium bovis; BCG; Calves; Protective efficacy
资金
- [CONACYTSAGARPAC02-2003-03]
The protective efficacy of Mycobacterium bovis BCG (1 x 10(6) single dose) was evaluated under field conditions. A total of 140 male Holstein Friesian calves, one to two week-old were selected. Two groups of 70 each were formed, one group was vaccinated and the other was injected with a placebo during their second week of age and followed until 12 months of age. The study considered a positive case of tuberculosis to be an animal that had a positive reaction to the three following tests in a row: tuberculin, IFN gamma PPD-B and IFN gamma ESAT6-CFP10 during the 12 months of exposure. The results showed a 59.4% efficacy (IC95%: 47.64-71.16). The non-vaccinated calves were 2.4 times more at risk of becoming infected (IC95%: 1.07-5.68) compared to vaccinated animals. As a complementary test a PCR test was performed using nasal exudates in some animals from both groups using a Mycobacterium complex detection kit. All the positive PCR reactions (5/44) were found in the non-vaccinated animals. These findings suggest that the use of the BCG vaccine, even though it is not capable of protecting 100%, does prevent TB vaccinated animals from excreting bacilli in their nasal secretions at their first year of age. (C) 2009 Elsevier Ltd. All rights reserved.
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